Creative Biostructure, a leading provider of structural biology tools and services, today announced the launch of its super-resolution localization microscopy service. This cutting-edge technique allows researchers to visualize biological structures and systems at the nanoscale, far beyond the resolution limits of traditional light microscopy.

“By harnessing the power of super resolution imaging microscopy, scientists can gain unprecedented insights into the intricate details of biological samples,” said Joanna, Chief Marketing Staff at Creative Biostructure. “Our team of experts is dedicated to helping researchers overcome the limitations of conventional microscopy and unlock new discoveries with this transformative technology.”

Creative Biostructure’s super-resolution localization microscopy service utilizes a range of techniques, including Ground State Depletion Followed by Individual Molecule Return (GSDIM), Photoactivated Localization Microscopy (PALM), and Stochastic Optical Reconstruction Microscopy (STORM microscopy). These methods involve the sequential activation and localization of fluorescent molecules to achieve resolutions as low as 20-30 nm.

The applications of this service are vast and powerful. Researchers can use super-resolution localization microscopy to:

• Isolate and image exosomes from different sources
• Visualize the ultrastructure of dyed, non-stained, and fluorescently labeled tissues and cells
• Observe protein localization and co-localization in multicolor fixed and living specimens
• Track dynamic changes in the ultrastructure of living cells
• Capture 3D images of fixed specimens and time-series data from living specimens
• Visualize cell membrane surface signals at the single-molecule level

“We are thrilled to offer this powerful service to the scientific community,” added Joanna. “By making super-resolution localization microscopy accessible, we aim to accelerate breakthroughs in fields ranging from basic biological research to drug discovery and diagnostics.”

Creative Biostructure’s team of experienced scientists and microscopists will work closely with clients to design and execute customized super-resolution imaging experiments. From sample preparation to data analysis, the company promises a seamless and collaborative experience.

Researchers interested in learning more about Creative Biostructure’s super-resolution localization microscopy service can visit https://www.creative-biostructure.com/super-resolution-localization-microscopy-gsdim-storm-service.htm.

Optical microscopes have been used to observe the microscopic biological world. However, the traditional optical microscope is limited by resolution and cannot observe smaller biomolecules and structures. With the emergence of scanning electron microscopy, scanning tunneling electron microscopy, and atomic force microscopy, it has become possible to achieve nanoscale resolution. Still, these techniques are destructive to samples and can only observe the surface, which is unsuitable for biological samples. To solve this problem, Creative Biostructure provides a variety of super-resolution imaging techniques suitable for imaging biological samples, including ground state depletion followed by individual molecule return (GSDIM), photoactivated localization microscopy (PALM), stochastic optical reconstruction microscopy (STORM), etc., to help understand biological structures and systems, and assist customers’ research.

About Creative Biostructure
Creative Biostructure is a leading provider of structural biology services, including protein expression and purification, crystallography, cryo EM, and super-resolution microscopy. The company is dedicated to helping researchers advance their understanding of biological systems and develop innovative therapeutics.

Creative Biostructure is specialized in providing cost-effective contract services to both academia and biotech/pharmaceutical industries in the field of structural biology and membrane protein technologies.

We have developed all-in-one, gene-to-structure pipelines for the structure determination of macromolecules of your interest. With a team of experienced professionals, Creative Biostructure is able to solve the structure of many challenging proteins including GPCRs, ion channels, transporters, enzymes and viral targets. We also provide a comprehensive list of products and other related services to facilitate your research in structural biology.

Creative Biostructure has also built up a unique and comprehensive Membrane Protein Screening Platform. Aiming at elucidating the fundamentals of membrane protein systems, we provide gene-to-structure services on the purification, crystallization, structure determination and analysis of various membrane proteins.

With our state-of-the-art platforms, we are offering our customers access to the latest tools, techniques and expertise for their structural biology projects with competitive pricing and short turnaround time. Our staff will be very glad to discuss the details of your project and develop experimental strategies tailored to your requirements.